Parathyroid Hormone-Related Protein Stimulates Plasma Renin
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چکیده
21 22 Corresponding author: 23 Prof. William H. Beierwaltes, Ph.D. 24 Senior Research Scientist, 25 Dept. Internal Medicine, 26 Hypertension and Vascular Research Div., 27 Henry Ford Hospital 28 7121 E&R Bldg., 2799 W. Grand Blvd., Detroit, MI 48202 29 313-916-7494, FAX 313-916-5284, [email protected] 30 31 32 33 34 35 Articles in PresS. Am J Physiol Endocrinol Metab (May 29, 2012). doi:10.1152/ajpendo.00020.2012
منابع مشابه
CALL FOR PAPERS Integrative Aspects of Renal Endocrinology Parathyroid hormone-related protein stimulates plasma renin activity via its anorexic effects on sodium chloride intake
Atchison DK, Westrick E, Szandzik DL, Gordish KL, Beierwaltes WH. Parathyroid hormone-related protein stimulates plasma renin activity via its anorexic effects on sodium chloride intake. Am J Physiol Endocrinol Metab 303: E457–E463, 2012. First published May 29, 2012; doi:10.1152/ajpendo.00020.2012.—Parathyroid hormone-related protein (PTHrP) increases renin release from isolated perfused kidne...
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Parathyroid hormone (PTH) is positively coupled to the generation of cAMP via its actions on the PTH1R and PTH2R receptors. Renin secretion from juxtaglomerular (JG) cells is stimulated by elevated intracellular cAMP, and every stimulus that increases renin secretion is thought to do so via increasing cAMP. Thus we hypothesized that PTH increases renin release from primary cultures of mouse JG ...
متن کاملParathyroid hormone-related protein stimulates plasma renin activity via its anorexic effects on sodium chloride intake.
Parathyroid hormone-related protein (PTHrP) increases renin release from isolated perfused kidneys and may act as an autacoid regulator of renin secretion, but its effects on renin in vivo are unknown. In vivo, PTHrP causes hypercalcemia and anorexia, which may affect renin. We hypothesized that chronically elevated PTHrP would increase plasma renin activity (PRA) indirectly via its anorexic ef...
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